Pfizer, maker of the most widely-used COVID-19 vaccine in the U.S., is testing a possible pill-based treatment for the virus using the same class of medication normally used to treat HIV.
Pfizer revealed the beginning of a stage 1 clinical trial utilizing a protease inhibitor tablet as a treatment for the infection on Tuesday. News of the trial comes months after Pfizer‘s COVID-19 vaccine, made in partnership with the German company BioNTech, was authorized for use and began to be administered in the U.S. and several other countries. The pill, currently called PF-07321332, might offer an extra weapon against the infection as fast-moving anomalies threaten to damage the efficiency of vaccines.
” Tackling the COVID-19 pandemic needs both avoidance through vaccine and targeted treatment for those who contract the infection,” Pfizer’s Chief Scientific Officer Mikael Dolsten stated in a statement obtained by Newsweek “Offered the way that SARS-CoV-2 is mutating and the continued global impact of COVID-19, it appears likely that it will be critical to have access to therapeutic choices both now and beyond the pandemic.”
” We have created PF-07321332 as a potential oral treatment that could be recommended at the first sign of infection, without requiring that clients are hospitalized or in important care,” included Dolsten.
The drug has actually shown activity against the infection that triggers COVID-19 in test tube experiments, in addition to activity against other kinds of coronaviruses, with the business stating that the outcomes raise the possibility of “possible use to address future coronavirus hazards.”
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Dolsten promoted both the oral medication and the business’s previously-developed experimental protease inhibitor treatment designed to be administered to hospitalized COVID-19 clients intravenously, which is currently going through stage 1b trials. Dolsten stated that two various approaches use “the capacity to create an end to end treatment paradigm that matches vaccination in cases where illness still takes place.”
While none of the vaccines provide total security against contracting the virus, they have actually been shown to considerably reduce infections and to be extremely reliable in preventing hospitalizations and death. Treatment alternatives could help alleviate concerns presented by the reality that some of the mutations currently making their method around the globe have revealed a minimal quantity of resistance to the vaccines, although both Pfizer and Moderna are developing booster shots or brand-new variations of vaccines to fight emerging variants.
As of Tuesday, over 64.6 million people in the U.S. had received at least one dosage of the Pfizer-BioNTech vaccine, according to the Centers for Disease Control and Prevention.
Protease inhibitors, which block virus recreation by binding to proteins called protease, were a class of drugs that transformed HIV treatment in the mid-1990 s. The drugs are likewise used against Hepatitis C infections, while researchers have investigated their use as treatments for specific types of cancer and parasitic infections.
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